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Retin-A (tretinoin) is a prescription drug used for the treatment of acne as a part of a comprehensive program. Retin-A comes in the form of cream, gel and liquid and is used topically. It’s important to avoid exposure to sunlight as you are more likely to get sunburn while using this medicine. Only a very small amount of this medicine should be applied. In fact, a pea-size amount of Retin-A is enough to cover the whole face. You can apply the medication using a clean cotton swab or a gauze pad. Unless otherwise recommended by your health care provider, apply this medicine once a day, and cover the area affected by acne in a thin layer.